Mass Effect: Andromeda is an action role-playing game in which the player takes control of either Scott or Sara Ryder from a third-person perspective. Both Ryders' appearances and first names can be determined by the player. The appearance of their father, Alec, is automatically adjusted based on the appearance of the Ryder twins. Upon beating the game, a New Game+ is unlocked, which allows the player to restart the game with certain bonuses and switch to playing as the other Ryder, if desired. Players can also choose to continue playing with their existing character and complete unfinished missions.

Unlike previous installments in the Mass Effect series, where players begin each new game by choosing from six different character classes that each have their own unique set of skills, players instead have free rein to assign any skills that they want and build towards a specialty over the course of the game. For example, if the player chooses to invest solely in biotic skills, Ryder will unlock the Adept profile, which results in bonuses related to that play style. Experience points are earned by completing missions, and there is no cap on the number of points that can be earned.[8] Once enough points are gained, Ryder levels up, which allows for the unlocking and upgrading of skills along a tree.[9] Points assigned to each skill can be constantly reallocated so that players can experiment with multiple gameplay approaches without having to restart their games and build up their skills from scratch again.[10]

Similar to its predecessors, the player can interact with characters in Mass Effect: Andromeda using a radial command menu where the player's dialogue options depend on wheel direction.[6] Around the wheel are four types of responses that shape each conversation: emotional, logical, professional, and casual.[11] In general, conversations are based on agreeing or disagreeing with participants.[12] During some conversations, the player is prompted with an "Impulse Action" that offers an additional choice to what is available on the dialogue wheel.[13] For example, an on-screen prompt to "shoot" might appear and be momentarily selectable.[14] By conversing with non-player characters, Ryder can develop friendships and, in some cases, romantic relationships with them over time.[15] During both dialogue and quest sequences, the player is sometimes tasked with making moral decisions that do not have a clear good/bad distinction but are intended to be more nuanced, marking a departure from the Paragon/Renegade morality system of prior titles in the series.[16] Mass Effect: Andromeda is an action role-playing video game developed by BioWare and published by Electronic Arts. The fourth major entry in the Mass Effect series, it was released in March 2017 for Microsoft Windows, PlayStation 4, and Xbox One. The game is set within the Andromeda Galaxy during the 29th century, where humanity is planning to populate new home worlds as part of a strategy called the Andromeda Initiative. The player assumes the role of either Scott or Sara Ryder, an inexperienced military recruit who joins the Initiative and wakes up in Andromeda following a 634-year sleeper ship journey. Events transpire that result in Ryder becoming humanity's Pathfinder, who is tasked with finding a new home world for humanity while also dealing with an antagonistic alien species known as the Kett, and uncovering the secrets of a mysterious synthetic intelligence species known as the Remnant.

For Mass Effect: Andromeda, BioWare incorporated a lighter tone than previous installments in the series, utilized open world elements, and placed an emphasis on exploration. Many of the series' traditional gameplay elements remained, while others were modified, such as combat, which is less cover-based and more mobile. The game is the largest in the series, and offers the player the freedom to focus on either the main quest or side quests. Its score was composed by John Paesano and aims to match the game's mood by capturing the adventure of space exploration.

In contrast to the original Mass Effect trilogy, which was spearheaded by BioWare's Edmonton studio, Mass Effect: Andromeda was handled by a new team out of Montreal. The game experienced a troubled production cycle that saw many members of its leadership team depart mid-project and numerous changes in creative vision. It was built using the Frostbite 3 engine, which required that BioWare construct all systems, tools, and assets from scratch as the series was previously built using Unreal Engine 3. Following the game's release, BioWare released several patches in response to critical feedback, but decided not to release further single-player downloadable content additions.

Mass Effect: Andromeda was announced in June 2015 and immediately became a highly anticipated game. Upon release, it received generally mixed reviews from critics, who praised the game's improved combat and visuals while criticizing its character animations, voice acting and technical issues. As of September 2017, the game has shipped over two million copies worldwide.